Europe Market Report for Minimally Invasive Interbody Devices 2017 - MedCore

TABLE OF CONTENTS I
LIST OF FIGURES XIV
LIST OF CHARTS XVII
EXECUTIVE SUMMARY 1
EUROPE MINIMALLY INVASIVE SPINAL IMPLANT MARKET OVERVIEW 1
COMPETITIVE ANALYSIS 4
MARKET TRENDS 7
MARKET DEVELOPMENTS 9
PROCEDURES COVERED 10
MARKETS INCLUDED 11
KEY REPORT UPDATES 12
VERSION HISTORY 12
RESEARCH METHODOLOGY 13
1.1 RESEARCH SCOPE 13
1.2 IDATA’S 9-STEP METHODOLOGY 13
Step 1: Project Initiation & Team Selection 13
Step 2: Prepare Data Systems and Perform Secondary Research 15
Step 3: Preparation for Interviews & Questionnaire Design 16
Step 4: Performing Primary Research 17
Step 5: Research Analysis: Establishing Baseline Estimates 19
Step 6: Market Forecast and Analysis 20
Step 7: Identify Strategic Opportunities 22
Step 8: Final Review and Market Release 23
Step 9: Customer Feedback and Market Monitoring 24
DISEASE OVERVIEW 25
2.1 INTRODUCTION 25
2.1.1 Degenerative Disc Disease 25
2.1.1.1 Disc Herniation 25
2.1.1.2 Stenosis 26
2.1.1.3 Spondyloisthesis 27
2.1.1.4 Arthritis 27
2.1.2 Spinal Deformities 27
2.1.2.1 Scoliosis 27
2.1.2.2 Kyphosis and Lordosis 28
2.1.3 Trauma and Tumor 29
2.1.4 Vertebral Compression Fractures 29
2.1.4.1 Osteoporosis 29
2.1.4.2 Vertebral Compression Fractures 30
PRODUCT ASSESSMENT 31
3.1 PRODUCT PORTFOLIOS 31
3.1.1 Interbody Devices 31
3.1.1.1 Approaches 32
3.1.1.1.1 ALIF 32
3.1.1.1.2 PLIF 32
3.1.1.1.3 TLIF 32
3.1.1.1.4 Minimally Invasive PLIF 32
3.1.1.1.5 Minimally Invasive TLIF 33
3.1.1.1.6 LLIF 34
3.1.1.1.7 OLIF 34
3.1.1.1.8 Cervical 34
3.1.1.1.9 VBR/Corpectomy 34
3.1.1.2 Materials 34
3.1.1.2.1 Metal 34
3.1.1.2.2 PEEK 35
3.1.1.2.3 Machined Bone Allograft 35
3.1 FDA RECALLS 38
3.1.1 Alphatec Spine 38
3.1.2 DePuy Synthes 38
3.1.3 Medtronic 39
3.1.4 Orthofix 40
3.1.5 Stryker 41
3.1.6 Zimmer Biomet 42
3.2 CLINICAL TRIALS 43
3.2.1 DePuy Synthes 43
3.2.2 Globus Medical 43
3.2.3 K2M 44
3.2.4 Medtronic 45
3.2.5 Stryker 46
3.2.6 Zimmer Biomet 47
COUNTRY PROFILES 48
4.1 INTRODUCTION 48
4.1.1.1 Population 48
4.1.1.2 Median Age 48
4.1.1.3 GDP Per Capita 48
4.1.1.4 Price Index 48
4.2 GERMANY 49
4.3 FRANCE 50
4.4 UNITED KINGDOM 51
4.5 ITALY 52
4.6 SPAIN 53
4.7 BENELUX 54
4.8 SCANDINAVIA 55
4.9 AUSTRIA 56
4.10 SWITZERLAND 57
4.11 PORTUGAL 58
MIS INTERBODY DEVICE MARKET 59
5.1 INTRODUCTION 59
5.1.1 Approach Types 60
5.1.1.1 Minimally Invasive Posterior Lumbar Interbody Fusion 60
5.1.1.2 Minimally Invasive Transforaminal Lumbar Interbody Fusion 60
5.1.1.3 Lateral Lumbar Interbody Fusion 61
5.1.1.4 Direct Lateral Interbody Fusion 61
5.1.1.5 eXtreme Lateral Interbody Fusion 61
5.1.1.6 Guided Lateral Interbody Fusion 62
5.1.1.7 Oblique Lateral Interbody Fusion 62
5.2 MARKET OVERVIEW 63
5.3 MARKET ANALYSIS AND FORECAST 67
5.3.1 Total MIS Interbody Device Market 67
5.3.2 MIPLIF Market 74
5.3.3 MITLIF Market 82
5.3.4 LLIF Market 90
5.3.5 OLIF Market 98
5.4 DRIVERS AND LIMITERS 106
5.4.1 Market Drivers 106
5.4.2 Market Limiters 107
5.5 COMPETITIVE MARKET SHARE ANALYSIS 109
ABBREVIATIONS 114
APPENDIX: COMPANY PRESS RELEASES 116

List of Chart
Chart 1 1: Minimally Invasive Spinal Implants Market by Segment, Europe, 2013 – 2023 2
Chart 1 2: Minimally Invasive Spinal Implants Market Overview, Europe, 2016 & 2023 3
Chart 4 1: Country Profile, Germany, 2016 49
Chart 4 2: Country Profile, France, 2016 50
Chart 4 3: Country Profile, United Kingdom, 2016 51
Chart 4 4: Country Profile, Italy, 2016 52
Chart 4 5: Country Profile, Spain, 2016 53
Chart 4 6: Country Profile, Benelux, 2016 54
Chart 4 7: Country Profile, Scandinavia, 2016 55
Chart 4 8: Country Profile, Austria, 2016 56
Chart 4 9: Country Profile, Switzerland, 2016 57
Chart 4 10: Country Profile, Portugal, 2016 58
Chart 5 1: MIS Interbody Device Market by Segment, Europe, 2013 – 2023 65
Chart 5 2: MIS Interbody Device Market Breakdown, Europe, 2016 66
Chart 5 3: MIS Interbody Device Market Breakdown, Europe, 2023 66
Chart 5 4: Total MIS Interbody Device Market, Europe, 2013 – 2023 68
Chart 5 5: MIPLIF Market, Europe, 2013 – 2023 76
Chart 5 6: MITLIF Market, Europe, 2013 – 2023 84
Chart 5 7: LLIF Market, Europe, 2013 – 2023 92
Chart 5 8: OLIF Market, Europe, 2013 – 2023 100
Chart 5 9: Leading Competitors, Total Cervical Fixation Market, Europe, 2016 113

List of Figures
Figure 1 1: Minimally Invasive Spinal Implants Market Share Ranking by Segment, Europe, 2016 (1 of 2) 4
Figure 1 2: Minimally Invasive Spinal Implants Market Share Ranking by Segment, Europe, 2016 (2 of 2) 5
Figure 1 3: Companies Researched in this Report, Europe, 2016 6
Figure 1 4: Factors Impacting the Minimally Invasive Spinal Implants Market by Segment, Europe (1 of 2) 7
Figure 1 5: Factors Impacting the Minimally Invasive Spinal Implants Market by Segment, Europe (2 of 2) 8
Figure 1 6: Recent Events in the Minimally Invasive Spinal Implants Market, Europe, 2015 – 2017 9
Figure 1 7: Minimally Invasive Spinal Implants Procedures Covered, Europe, 2016 10
Figure 1 8: Minimally Invasive Spinal Implants Markets Covered, Europe, 2016 11
Figure 1 9: Key Report Updates 12
Figure 1 10: Version History 12
Figure 3 1: Interbody Devices by Company (1 of 2) 36
Figure 3 2: Interbody Devices by Company (2 of 2) 37
Figure 3 3: Class 2 Device Recall Alphatec Spine 38
Figure 3 4: Class 2 Device Recall DePuy Synthes 38
Figure 3 5: Class 2 Device Recall DePuy Synthes 38
Figure 3 6: Class 2 Device Recall Medtronic 39
Figure 3 7: Class 2 Device Recall Medtronic 39
Figure 3 8: Class 2 Device Recall Medtronic 39
Figure 3 9: Class 2 Device Recall Medtronic 40
Figure 3 10: Class 2 Device Recall Orthofix 40
Figure 3 11: Class 2 Device Recall Orthofix 40
Figure 3 12: Class 2 Device Recall Orthofix 41
Figure 3 13: Class 2 Device Recall Orthofix 41
Figure 3 14: Class 2 Device Recall Stryker 41
Figure 3 15: Class 2 Device Recall Stryker 42
Figure 3 16: Class 2 Device Recall Zimmer Biomet 42
Figure 3 17: An ACDF Multi-Center Study Using ViviGen Cellular Bone Matrix 43
Figure 3 18: A Retrospective Study Using CALIBER® TLIF Expandable Spacer in the Treatment of DDD: 2 Year Follow-up. 43
Figure 3 19: Comparing Pedicle Screw Systems for the Treatment of Adolescent Paediatric Spine Deformity 44
Figure 3 20: A Prospective, 5-Year Global Study on MAST™ 45
Figure 3 21: Spinal Cord Stimulation to Treat Post-operative Atrial Fibrillation (SCS-PAF) 45
Figure 3 22: OLIF25™ /OLIF51™ Study 46
Figure 3 23: AccuLIF® PROSPECTIVE PATIENT OUTCOMES STUDY (APROPOS) 46
Figure 3 24: Post-Market Surveillance Study of the TM Ardis Interbody Fusion System 47
Figure 5 1: MIS Interbody Device Market by Segment, Europe, 2013 – 2023 (€M) 64
Figure 5 2: MIS Interbody Device Market by Segment, Europe, 2013 – 2023 (US$M) 64
Figure 5 3: Total MIS Interbody Device Market, Europe, 2013 – 2023 67
Figure 5 4: Units Sold by Country, Total MIS Interbody Device Market, Europe, 2013 – 2023 69
Figure 5 5: Average Selling Price by Country, Total MIS Interbody Device Market, Europe, 2013 – 2023 (€) 70
Figure 5 6: Average Selling Price by Country, Total MIS Interbody Device Market, Europe, 2013 – 2023 (US$) 71
Figure 5 7: Market Value by Country, Total MIS Interbody Device Market, Europe, 2013 – 2023 (€M) 72
Figure 5 8: Market Value by Country, Total MIS Interbody Device Market, Europe, 2013 – 2023 (US$M) 73
Figure 5 9: MIPLIF Market, Europe, 2013 – 2023 75
Figure 5 10: Units Sold by Country, MIPLIF Market, Europe, 2013 – 2023 77
Figure 5 11: Average Selling Price by Country, MIPLIF Market, Europe, 2013 – 2023 (€) 78
Figure 5 12: Average Selling Price by Country, MIPLIF Market, Europe, 2013 – 2023 (US$) 79
Figure 5 13: Market Value by Country, MIPLIF Market, Europe, 2013 – 2023 (€M) 80
Figure 5 14: Market Value by Country, MIPLIF Market, Europe, 2013 – 2023 (US$M) 81
Figure 5 15: MITLIF Market, Europe, 2013 – 2023 83
Figure 5 16: Units Sold by Country, MITLIF Market, Europe, 2013 – 2023 85
Figure 5 17: Average Selling Price by Country, MITLIF Market, Europe, 2013 – 2023 (€) 86
Figure 5 18: Average Selling Price by Country, MITLIF Market, Europe, 2013 – 2023 (US$) 87
Figure 5 19: Market Value by Country, MITLIF Market, Europe, 2013 – 2023 (€M) 88
Figure 5 20: Market Value by Country, MITLIF Market, Europe, 2013 – 2023 (US$M) 89
Figure 5 21: LLIF Market, Europe, 2013 – 2023 91
Figure 5 22: Units Sold by Country, LLIF Market, Europe, 2013 – 2023 93
Figure 5 23: Average Selling Price by Country, LLIF Market, Europe, 2013 – 2023 (€) 94
Figure 5 24: Average Selling Price by Country, LLIF Market, Europe, 2013 – 2023 (US$) 95
Figure 5 25: Market Value by Country, LLIF Market, Europe, 2013 – 2023 (€M) 96
Figure 5 26: Market Value by Country, LLIF Market, Europe, 2013 – 2023 (US$M) 97
Figure 5 27: OLIF Market, Europe, 2013 – 2023 99
Figure 5 28: Units Sold by Country, OLIF Market, Europe, 2013 – 2023 101
Figure 5 29: Average Selling Price by Country, OLIF Market, Europe, 2013 – 2023 (€) 102
Figure 5 30: Average Selling Price by Country, OLIF Market, Europe, 2013 – 2023 (US$) 103
Figure 5 31: Market Value by Country, OLIF Market, Europe, 2013 – 2023 (€M) 104
Figure 5 32: Market Value by Country, OLIF Market, Europe, 2013 – 2023 (US$M) 105
Figure 5 33: Drivers and Limiters, Dental Cement Market, Europe, 2016 108
Figure 5 34: Leading Competitors, MIS Interbody Device Market, Europe, 2016 112