Gastric and Gastroesophageal Junction Adenocarcinoma - 5EU Drug Forecast and Market Analysis to 2024

1 Table of Contents
1.1 List of Tables
1.2 List of Figures
2 Introduction
2.1 Catalyst
2.2 Related Reports
2.3 Upcoming Related Reports
3 Disease Overview
3.1 Etiology and Pathophysiology
3.1.1 Etiology
3.1.2 Pathophysiology
3.1.3 Biomarkers/Targets of Interest
3.2 Staging
3.3 Symptoms
3.4 Prognosis
3.5 Quality of Life
4 Disease Management
4.1 Diagnosis and Treatment Overview
4.1.1 Screening
4.1.2 Diagnosis
4.1.3 Treatment Guidelines and Leading Prescribed Drugs
4.1.4 Clinical Practice
4.2 France
4.2.1 Screening and Diagnosis
4.2.2 Clinical Practice
4.3 Germany
4.3.1 Screening and Diagnosis
4.3.2 Clinical Practice
4.4 Italy
4.4.1 Screening and Diagnosis
4.4.2 Clinical Practice
4.5 Spain
4.5.1 Screening and Diagnosis
4.5.2 Clinical Practice
4.6 UK
4.6.1 Screening and Diagnosis
4.6.2 Clinical Practice
5 Competitive Assessment
5.1 Overview
5.2 HER2-Targeted Therapy
5.2.1 Herceptin (trastuzumab)
5.3 Angiogenesis Inhibitors
5.3.1 Cyramza (ramucirumab)
5.3.2 Aitan (apatinib)
5.4 Chemotherapies
5.4.1 TS-1 (tegafur, gimeracil, oteracil)
5.4.2 Abraxane (nab-paclitaxel)
6 Unmet Need and Opportunity
6.1 Overview
6.2 First-Line Therapy for HER2-Negative Patients
6.2.1 Unmet Need
6.2.2 Gap Analysis
6.2.3 Opportunity
6.3 New Molecular Targets for Targeted Therapies
6.3.1 Unmet Need
6.3.2 Gap Analysis
6.3.3 Opportunity
6.4 Effective Perioperative and Postoperative Therapies
6.4.1 Unmet Need
6.4.2 Gap Analysis
6.4.3 Opportunity
6.5 More Efficacious HER2-Targeted Therapies
6.5.1 Unmet Need
6.5.2 Gap Analysis
6.5.3 Opportunity
6.6 Peritoneal Metastases
6.6.1 Unmet Need
6.6.2 Gap Analysis
6.6.3 Opportunity
6.7 Better Clinical Trial Design
6.7.1 Unmet Need
6.7.2 Gap Analysis
6.7.3 Opportunity
6.8 Early Detection of Gastric and Gastroesophageal Adenocarcinomas
6.8.1 Unmet Need
6.8.2 Gap Analysis
6.8.3 Opportunity
7 Pipeline Assessment
7.1 Overview
7.2 Promising Drugs in Phase III Clinical Development
7.3 HER2-Targeted Therapies
7.3.1 Kadcyla (T-DM1; trastuzumab emtansine)
7.3.2 Perjeta (pertuzumab)
7.4 Immune Checkpoint Inhibitors
7.4.1 Keytruda (pembrolizumab)
7.4.2 Opdivo (nivolumab)
7.5 Further Strategies for G/GEJAC Treatment
7.5.1 Napabucasin
7.5.2 Lynparza (olaparib)
7.5.3 Nimotuzumab
7.5.4 TAS-118
7.6 Early/Near-Phase III Pipeline Drugs
7.6.1 GS-5745
7.6.2 Masitinib
7.7 Promising Drugs in Early-Stage Development
7.7.1 Immune Checkpoint Inhibitors
7.7.2 MET-Targeting Drugs
7.7.3 Antibody-Drug Conjugates
7.8 Biosimilars
8 Market Outlook
8.1 5EU
8.1.1 Forecast
8.1.2 Key Events
8.1.3 Drivers and Barriers - France
8.1.4 Drivers and Barriers - Germany
8.1.5 Drivers and Barriers - Italy
8.1.6 Drivers and Barriers - Spain
8.1.7 Drivers and Barriers - UK
9 Appendix
9.1 Bibliography
9.2 Abbreviations
9.3 Methodology
9.4 Forecasting Methodology
9.4.1 Diagnosed G/GEJAC Patients
9.4.2 Percent of Drug-Treated Patients
9.4.3 Drugs Included in Each Therapeutic Class
9.4.4 Launch and Patent Expiry Dates
9.4.5 General Pricing Assumptions
9.4.6 Individual Drug Assumptions
9.4.7 Generic Erosion
9.4.8 Pricing of Pipeline Agents
9.5 Primary Research - Key Opinion Leaders Interviewed for this Report
9.6 Primary Research - High-Prescriber Survey
9.7 About the Authors
9.8 About GlobalData
9.9 Disclaimer

1.1 List of Tables
Table 1: Stage Definitions for Gastric Cancer
Table 2: Symptoms of Gastric Cancer
Table 3: Prognosis of Gastric Cancer in the US and UK
Table 4: Clinical Guidelines for Gastric Cancer
Table 5: Generic Chemotherapy Regimens Indicated for Gastric Cancer
Table 6: Country Profile - France
Table 7: Country Profile - Germany
Table 8: Country Profile - Italy
Table 9: Country Profile - Spain
Table 10: Country Profile - UK
Table 11: Leading Treatments for G/GEJAC, 2015
Table 12: Product Profile - Herceptin
Table 13: Summary of Results from the ToGA Trial of Herceptin plus FC
Table 14: Summary of the Results of the Analysis of the HER2 IHC3+ or IHC2+/FISH+ Subgroup
Table 15: Summary of AEs from the ToGA Trial of Herceptin plus FC
Table 16: Herceptin SWOT Analysis, 2015
Table 17: Global Sales Forecasts ($m) for Herceptin, 2014-2024
Table 18: Product Profile - Cyramza
Table 19: Summary of the Results from the REGARD of Cyramza
Table 20: Summary of the Results from the RAINBOW Trial of Cyramza plus Paclitaxel
Table 21: Summary of Trial Results of Cyramza in Combination with mFOLFOX6 in the First-Line Setting
Table 22: Summary of AEs from the REGARD Trial of Cyramza Monotherapy
Table 23: Summary of AEs from the RAINBOW Trial of Cyramza plus Paclitaxel
Table 24: Cyramza SWOT Analysis, 2015
Table 25: Global Sales Forecasts ($m) for Cyramza, 2014-2024
Table 26: Product Profile - Aitan
Table 27: Summary of Aitan Trial Results
Table 28: Summary of AEs from Phase III Trial of Aitan
Table 29: Aitan SWOT Analysis, 2015
Table 30: Global Sales Forecasts ($m) for Aitan, 2014-2024
Table 31: Product Profile - TS-1
Table 32: Summary of the Results of Three Studies of TS-1 Monotherapy
Table 33: Summary of the Results from the ACTS-GC Study of TS-1
Table 34: Summary of TS-1 in the DIGEST trial
Table 35: Summary of AEs from ACTS=GS Trial of TS-1 Adjuvant Treatment
Table 36: Summary of AEs from Trial of TS-1 plus Cisplatin
Table 37: TS-1 SWOT Analysis, 2015
Table 38: Global Sales Forecasts ($m) for TS-1, 2014-2024
Table 39: Product Profile - Abraxane
Table 40: Summary of Results from a Phase II Trial of Abraxane
Table 41: Safety of Abraxane
Table 42: Abraxane SWOT Analysis, 2015
Table 43: Global Sales Forecasts ($m) for Abraxane, 2014-2024
Table 44: Unmet Needs and Opportunities in G/GEJAC
Table 45: Product Profile - Kadcyla
Table 46: Kadcyla SWOT Analysis, 2015
Table 47: Product Profile - Perjeta
Table 48: Summary of the Results of the Phase IIa Trial of the Herceptin/Perjeta-CX Combination
Table 49: Safety of the Herceptin/Perjeta-CX Combination
Table 50: Perjeta SWOT Analysis, 2015
Table 51: Global Sales Forecasts ($m) for Perjeta, 2014-2024
Table 52: Product Profile - Keytruda
Table 53: Summary of the Results of the KEYNOTE-012 Trial of Keytruda
Table 54: Keytruda SWOT Analysis, 2015
Table 55: Global Sales Forecasts ($m) for Keytruda, 2014-2024
Table 56: Product Profile - Opdivo
Table 57: Opdivo SWOT Analysis, 2015
Table 58: Global Sales Forecasts ($m) for Opdivo, 2014-2024
Table 59: Product Profile - Napabucasin
Table 60: Summary of the Results from the Phase Ib/II Trial of Napabucasin
Table 61: Napabucasin SWOT Analysis, 2015
Table 62: Global Sales Forecasts ($m) for Napabucasin, 2014-2024
Table 63: Product Profile - Lynparza
Table 64: Summary of Results of the Phase II Trial of Lynparza
Table 65: Summary of AEs from Phase II Trial of Lynparza
Table 66: Lynparza SWOT Analysis, 2015
Table 67: Global Sales Forecasts ($m) for Lynparza, 2014-2024
Table 68: Product Profile - Nimotuzumab
Table 69: Summary of the Results of the Phase II Trial of Nimotuzumab in Unselected Patients
Table 70: Summary of the Results of the Subgroup Analysis of Nimotuzumab in EGFR-Positive Patients
Table 71: Summary of AEs from the Phase II Trial of Nimotuzumab in Combination with Irinotecan
Table 72: Nimotuzumab SWOT Analysis, 2015
Table 73: Global Sales Forecasts ($m) for nimotuzumab, 2014-2024
Table 74: Product Profile - TAS-118
Table 75: TAS-118 SWOT Analysis, 2015
Table 76: Global Sales Forecasts ($m) for TAS-118, 2014-2024
Table 77: Product Profile - GS-5745
Table 78: GS-5745 SWOT Analysis
Table 79: Product Profile - Masitinib
Table 80: Summary of the Results of the Phase II Trial of the Masitinib-Chemotherapy Combinations
Table 81: Summary of AEs from the Phase II Trial of the Masitinib-Chemotherapy Combinations
Table 82: Masitinib SWOT Analysis, 2013
Table 83: Early-Stage Immune Checkpoint Inhibitors
Table 84: Early-Stage MET-Targeting Drugs
Table 85: Early-Stage Antibody-Drug-Conjugates
Table 86: Marketed or Phase III Trastuzumab Biosimilars
Table 87: Sales Forecast ($m) for G/GEJAC in the 5EU, 2014-2024
Table 88: Key Events Impacting Sales for G/GEJAC in the 5EU, 2014-2024
Table 89: G/GEJAC Market in France - Drivers and Barriers, 2015
Table 90: G/GEJAC Market in Germany - Drivers and Barriers, 2015
Table 91: G/GEJAC Market in Italy - Drivers and Barriers, 2015
Table 92: G/GEJAC Market in Spain - Drivers and Barriers, 2015
Table 93: G/GEJAC Market in the UK - Drivers and Barriers, 2015
Table 94: Key Launch Dates
Table 95: Key Patent Expiries
Table 96 Average Body Weight and Surface Area Across the 8MM
Table 97: Average Cost of Therapy of Herceptin
Table 98: Average Cost of Therapy of Cyramza
Table 99: Average Cost of Therapy of TS-1
Table 100: Average Cost of Therapy of Abraxane
Table 101: High-Prescribing Physicians Surveyed by Country

1.2 List of Figures
Figure 1: Treatment Flowchart for Localized Gastric Cancer
Figure 2: Treatment Flowchart for Locoregional Gastric cancer
Figure 3: Treatment Flowchart for Metastatic Gastric Cancer
Figure 4: Herceptin’s Development in G/GEJAC
Figure 5: Development of Cyramza in G/GEJAC
Figure 6: Development of TS-1 in G/GEJAC
Figure 7: Development of Abraxane in Gastric Cancer
Figure 8: G/GEJAC - Phase III Pipeline, 2015
Figure 9: Competitive Assessment of Late-Stage Pipeline Agents in G/GEJAC, 2014-2024
Figure 10: Kadcyla’s Development in G/GEJAC
Figure 11: Clinical and Commercial Positioning of Kadcyla
Figure 12: Perjeta’s Development in G/GEJAC
Figure 13: Clinical and Commercial Positioning of Perjeta
Figure 14: Keytruda’s Development in G/GEJAC
Figure 15: Clinical and Commercial Positioning of Keytruda
Figure 16: Opdivo’s Development in G/GEJAC
Figure 17: Clinical and Commercial Positioning of Opdivo
Figure 18: Napabucasin ’s Development in G/GEJAC
Figure 19: Clinical and Commercial Positioning of Napabucasin
Figure 20: Lynparza’s Development in G/GEJAC
Figure 21: Clinical and Commercial Positioning of Lynparza
Figure 22: Nimotuzumab’s Development in Gastric Cancer
Figure 23: Clinical and Commercial Positioning of Nimotuzumab
Figure 24: TAS-118’s Development in Gastric Cancer
Figure 25: Clinical and Commercial Positioning of TAS-118
Figure 26: GS-5745 ’s Development in G/GEJAC
Figure 27: Clinical and Commercial Positioning of GS-5745
Figure 28: Clinical and Commercial Positioning of masitinib
Figure 29: Sales for G/GEJAC in the 5EU by Drug Class, 2014-2024