Mosquito-borne Diseases Drug Development Pipeline Review, 2018

1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 5
1.2 List of Figures 7
2 Introduction 8
2.1 Mosquito-borne Diseases Report Coverage 8
2.2 West Nile Virus Infections - Overview 8
2.3 Japanese Encephalitis - Overview 8
2.4 Yellow Fever - Overview 8
2.5 Malaria - Overview 8
3 Therapeutics Development 9
3.1 West Nile Virus Infections 9
3.2 Japanese Encephalitis 14
3.3 Yellow Fever 18
3.4 Malaria 22
4 Therapeutics Assessment 38
4.1 West Nile Virus Infections 38
4.2 Japanese Encephalitis 44
4.3 Yellow Fever 47
4.4 Malaria 53
5 Companies Involved in Therapeutics Development 62
5.1 West Nile Virus Infections 62
5.2 Japanese Encephalitis 65
5.3 Yellow Fever 70
5.4 Malaria 74
6 Dormant Projects 102
6.1 West Nile Virus Infections 102
6.2 Japanese Encephalitis 104
6.3 Yellow Fever 105
6.4 Malaria 106
7 Discontinued Products 114
7.1 Japanese Encephalitis 114
7.2 Malaria 114
8 Product Development Milestones 116
8.1 West Nile Virus Infections 116
8.2 Yellow Fever 121
8.3 Malaria 124
9 Appendix 141
9.1 Methodology 141
9.2 Coverage 141
9.3 Secondary Research 141
9.4 Primary Research 141
9.5 Expert Panel Validation 141
9.6 Contact Us 142
9.7 Disclaimer 142

List of Tables
1.1 List of Tables
Table 1: Number of Products under Development for West Nile Virus Infections 9
Table 2: Number of Products under Development by Companies, West Nile Virus Infections 10
Table 3: Number of Products under Development by Universities/Institutes, West Nile Virus Infections 11
Table 4: Products under Development by Companies, West Nile Virus Infections 12
Table 5: Products under Development by Universities/Institutes, West Nile Virus Infections 13
Table 6: Number of Products under Development for Japanese Encephalitis 14
Table 7: Number of Products under Development by Companies, Japanese Encephalitis 15
Table 8: Number of Products under Development by Universities/Institutes, Japanese Encephalitis 16
Table 9: Products under Development by Companies, Japanese Encephalitis 17
Table 10: Products under Development by Universities/Institutes, Japanese Encephalitis 17
Table 11: Number of Products under Development for Yellow Fever 18
Table 12: Number of Products under Development by Companies, Yellow Fever 19
Table 13: Number of Products under Development by Universities/Institutes, Yellow Fever 20
Table 14: Products under Development by Companies, Yellow Fever 21
Table 15: Products under Development by Universities/Institutes, Yellow Fever 21
Table 16: Number of Products under Development for Malaria 22
Table 17: Number of Products under Development by Companies, Malaria 24
Table 18: Number of Products under Development by Universities/Institutes, Malaria 27
Table 19: Products under Development by Companies, Malaria 29
Table 20: Products under Development by Universities/Institutes, Malaria 33
Table 21: Number of Products by Stage and Target, West Nile Virus Infections 39
Table 22: Number of Products by Stage and Mechanism of Action, West Nile Virus Infections 40
Table 23: Number of Products by Stage and Route of Administration, West Nile Virus Infections 42
Table 24: Number of Products by Stage and Molecule Type, West Nile Virus Infections 43
Table 25: Number of Products by Stage and Target, Japanese Encephalitis 44
Table 26: Number of Products by Stage and Mechanism of Action, Japanese Encephalitis 44
Table 27: Number of Products by Stage and Route of Administration, Japanese Encephalitis 45
Table 28: Number of Products by Stage and Molecule Type, Japanese Encephalitis 47
Table 29: Number of Products by Stage and Target, Yellow Fever 48
Table 30: Number of Products by Stage and Mechanism of Action, Yellow Fever 50
Table 31: Number of Products by Stage and Route of Administration, Yellow Fever 51
Table 32: Number of Products by Stage and Molecule Type, Yellow Fever 53
Table 33: Number of Products by Stage and Target, Malaria 54
Table 34: Number of Products by Stage and Mechanism of Action, Malaria 57
Table 35: Number of Products by Stage and Route of Administration, Malaria 59
Table 36: Number of Products by Stage and Molecule Type, Malaria 61
Table 37: West Nile Virus Infections - Pipeline by CEL-SCI Corp 62
Table 38: West Nile Virus Infections - Pipeline by Ennaid Therapeutics LLC 62
Table 39: West Nile Virus Infections - Pipeline by Hawaii Biotech Inc 63
Table 40: West Nile Virus Infections - Pipeline by Hemispherx Biopharma Inc 63
Table 41: West Nile Virus Infections - Pipeline by Kineta Inc 64
Table 42: West Nile Virus Infections - Pipeline by Ology Bioservices Inc 64
Table 43: West Nile Virus Infections - Pipeline by Plex Pharmaceuticals Inc 65
Table 44: Japanese Encephalitis - Pipeline by Abivax SA 65
Table 45: Japanese Encephalitis - Pipeline by Adimmune Corp 66
Table 46: Japanese Encephalitis - Pipeline by Cadila Healthcare Ltd 66
Table 47: Japanese Encephalitis - Pipeline by Ennaid Therapeutics LLC 67
Table 48: Japanese Encephalitis - Pipeline by Indian Immunologicals Ltd 67
Table 49: Japanese Encephalitis - Pipeline by Kineta Inc 68
Table 50: Japanese Encephalitis - Pipeline by Livzon Pharmaceutical Group Inc 68
Table 51: Japanese Encephalitis - Pipeline by Panacea Biotec Ltd 69
Table 52: Japanese Encephalitis - Pipeline by Sinovac Biotech Ltd 69
Table 53: Yellow Fever - Pipeline by Bavarian Nordic A/S 70
Table 54: Yellow Fever - Pipeline by BioCryst Pharmaceuticals Inc 71
Table 55: Yellow Fever - Pipeline by Emergex Vaccines Ltd 71
Table 56: Yellow Fever - Pipeline by Ennaid Therapeutics LLC 71
Table 57: Yellow Fever - Pipeline by iBio Inc 72
Table 58: Yellow Fever - Pipeline by Ology Bioservices Inc 72
Table 59: Yellow Fever - Pipeline by Sihuan Pharmaceutical Holdings Group Ltd 73
Table 60: Yellow Fever - Pipeline by Valneva SE 73
Table 61: Malaria - Pipeline by 4SC AG 74
Table 62: Malaria - Pipeline by AbbVie Inc 75
Table 63: Malaria - Pipeline by Agilvax Inc 75
Table 64: Malaria - Pipeline by Akshaya Bio Inc 75
Table 65: Malaria - Pipeline by AlfaSigma SpA 76
Table 66: Malaria - Pipeline by Allergy Therapeutics Plc 76
Table 67: Malaria - Pipeline by Altimmune Inc 77
Table 68: Malaria - Pipeline by Artificial Cell Technologies Inc 77
Table 69: Malaria - Pipeline by AstraZeneca Plc 78
Table 70: Malaria - Pipeline by Bharat Biotech Ltd 78

List of Figures
1.2 List of Figures
Figure 1: Number of Products under Development for West Nile Virus Infections 9
Figure 2: Number of Products under Development by Companies, West Nile Virus Infections 10
Figure 3: Number of Products under Development by Universities/Institutes, West Nile Virus Infections 11
Figure 4: Number of Products under Development for Japanese Encephalitis 14
Figure 5: Number of Products under Development by Companies, Japanese Encephalitis 15
Figure 6: Number of Products under Development by Universities/Institutes, Japanese Encephalitis 16
Figure 7: Number of Products under Development for Yellow Fever 18
Figure 8: Number of Products under Development by Companies, Yellow Fever 19
Figure 9: Number of Products under Development by Universities/Institutes, Yellow Fever 20
Figure 10: Number of Products under Development for Malaria 22
Figure 11: Number of Products under Development by Companies, Malaria 23
Figure 12: Number of Products under Development by Universities/Institutes, Malaria 26
Figure 13: Number of Products by Targets, West Nile Virus Infections 38
Figure 14: Number of Products by Stage and Targets, West Nile Virus Infections 38
Figure 15: Number of Products by Mechanism of Actions, West Nile Virus Infections 39
Figure 16: Number of Products by Stage and Mechanism of Actions, West Nile Virus Infections 40
Figure 17: Number of Products by Routes of Administration, West Nile Virus Infections 41
Figure 18: Number of Products by Stage and Routes of Administration, West Nile Virus Infections 41
Figure 19: Number of Products by Molecule Types, West Nile Virus Infections 42
Figure 20: Number of Products by Stage and Molecule Types, West Nile Virus Infections 43
Figure 21: Number of Products by Routes of Administration, Japanese Encephalitis 44
Figure 22: Number of Products by Stage and Routes of Administration, Japanese Encephalitis 45
Figure 23: Number of Products by Molecule Types, Japanese Encephalitis 46
Figure 24: Number of Products by Stage and Molecule Types, Japanese Encephalitis 46
Figure 25: Number of Products by Targets, Yellow Fever 47
Figure 26: Number of Products by Stage and Targets, Yellow Fever 48
Figure 27: Number of Products by Mechanism of Actions, Yellow Fever 49
Figure 28: Number of Products by Stage and Mechanism of Actions, Yellow Fever 49
Figure 29: Number of Products by Routes of Administration, Yellow Fever 50
Figure 30: Number of Products by Stage and Routes of Administration, Yellow Fever 51
Figure 31: Number of Products by Molecule Types, Yellow Fever 52
Figure 32: Number of Products by Stage and Molecule Types, Yellow Fever 52
Figure 33: Number of Products by Targets, Malaria 53
Figure 34: Number of Products by Stage and Targets, Malaria 54
Figure 35: Number of Products by Top 10 Mechanism of Actions, Malaria 56
Figure 36: Number of Products by Stage and Mechanism of Actions, Malaria 56
Figure 37: Number of Products by Routes of Administration, Malaria 58
Figure 38: Number of Products by Stage and Routes of Administration, Malaria 59
Figure 39: Number of Products by Top 10 Molecule Types, Malaria 60
Figure 40: Number of Products by Stage and Top 10 Molecule Types, Malaria 60