Hepatitis Drug Development Pipeline Review, 2017

Home/Hepatitis Drug Development Pipeline Review, 2017

Hepatitis Drug Development Pipeline Review, 2017

Drug Pipeline, Drug Discovery, Pharma & Healthcare

Publication ID:

GBI0817002

Publication Date:

August 01, 2017

Pages:

209

Publisher:

GBI Research

Region:

Global

$3,995.00

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Description

Hepatitis Drug Development Pipeline Review, 2017

Summary

This report provides an overview of the hepatitis pipeline landscape. The report provides comprehensive information on the therapeutics under development and key players involved in therapeutic development for hepatitis A, B, C and D, and features dormant and discontinued projects.

Hepatitis is a contagious viral infection affecting the liver, which may spread on contact with infected blood. It may be a mild condition or may extend over a longer span of time leading to various complications. The characteristic symptoms include abdominal pain, fatigue, fever, jaundice, loss of appetite, nausea and vomiting. The predisposing factors of hepatitis typically include dialysis, organ transplant and blood transfusion and the offspring of an infected mother also has high chances of contracting the disease.

Owing to differences in prevalence, hepatitis A and D have far smaller pipelines than hepatitis B and C; the size of these pipelines ranges from seven products in hepatitis A to 182 in hepatitis B and 199 in hepatitis C. Many of the companies who are actively fielding products in the larger two hepatitis subtypes are simultaneously developing products for both. While in hepatitis A, B and D, viral surface antigens and interferons are commonly targeted, a far wider range of proteins, including non-structural proteins, are the most common targets in hepatitis C.

Scope

- Which companies are the most active within the pipeline for hepatitis therapeutics?
- Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
- To what extent do universities and institutions play a role within this pipeline, compared to pharmaceutical companies?
- What are the most important R&D milestones and data publications to have happened in the field of hepatitis?

Reasons to buy

- Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication
- Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each
- Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these
- Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration

Table of Contents

Table of Contents
GBI Research Report Guidance 2
Executive Summary 3
Table of Contents 4
List of Tables 6
List of Figures 11
Introduction 12
Hepatitis Report Coverage 12
Hepatitis A - Overview 12
Hepatitis B - Overview 12
Hepatitis C - Overview 12
Hepatitis D - Overview 12
Therapeutics Development 13
Hepatitis A 13
Hepatitis B 17
Hepatitis C 30
Hepatitis D 43
Therapeutics Assessment 46
Hepatitis A 46
Hepatitis B 48
Hepatitis C 56
Hepatitis D 65
Companies Involved in Therapeutics Development 72
Hepatitis A 72
Hepatitis B 74
Hepatitis C 116
Hepatitis D 151
Dormant Projects 155
Hepatitis A 155
Hepatitis B 155
Hepatitis C 159
Hepatitis D 169
Discontinued Products 170
Hepatitis B 170
Hepatitis C 170
Hepatitis D 173
Product Development Milestones 174
Hepatitis B 174
Hepatitis C 182
Hepatitis D 196
Appendix 208
Methodology 208
Coverage 208
Secondary Research 208
Primary Research 208
Expert Panel Validation 208
Contact Us 208
Disclaimer 209

List of Tables
List of Tables
Number of Products under Development for Hepatitis A 13
Number of Products under Development by Companies, Hepatitis A 14
Number of Products under Development by Universities/Institutes, Hepatitis A 15
Products under Development by Companies, Hepatitis A 16
Products under Development by Universities/Institutes, Hepatitis A 16
Number of Products under Development for Hepatitis B 17
Number of Products under Development by Companies, Hepatitis B 19
Number of Products under Development by Universities/Institutes, Hepatitis B 22
Products under Development by Companies, Hepatitis B 23
Products under Development by Universities/Institutes, Hepatitis B 29
Number of Products under Development for Hepatitis C 30
Number of Products under Development by Companies, Hepatitis C 32
Number of Products under Development by Universities/Institutes, Hepatitis C 35
Products under Development by Companies, Hepatitis C 36
Products under Development by Universities/Institutes, Hepatitis C 41
Number of Products under Development for Hepatitis D 43
Number of Products under Development by Companies, Hepatitis D 44
Number of Products under Development by Universities/Institutes, Hepatitis D 45
Products under Development by Companies, Hepatitis D 45
Products under Development by Universities/Institutes, Hepatitis D 45
Number of Products by Stage and Target, Hepatitis A 46
Number of Products by Stage and Molecule Type, Hepatitis A 47
Number of Products by Stage and Target, Hepatitis B 49
Number of Products by Stage and Mechanism of Action, Hepatitis B 51
Number of Products by Stage and Route of Administration, Hepatitis B 53
Number of Products by Stage and Molecule Type, Hepatitis B 55
Number of Products by Stage and Target, Hepatitis C 57
Number of Products by Stage and Mechanism of Action, Hepatitis C 60
Number of Products by Stage and Route of Administration, Hepatitis C 63
Number of Products by Stage and Molecule Type, Hepatitis C 65
Number of Products by Stage and Target, Hepatitis D 66
Number of Products by Stage and Mechanism of Action, Hepatitis D 68
Number of Products by Stage and Route of Administration, Hepatitis D 70
Number of Products by Stage and Molecule Type, Hepatitis D 71
Hepatitis A - Pipeline by Beijing Minhai Biotechnology Co Ltd 72
Hepatitis A - Pipeline by Indian Immunologicals Ltd 72
Hepatitis A - Pipeline by Sinovac Biotech Ltd 73
Hepatitis A - Pipeline by Zydus Cadila Healthcare Ltd 73
Hepatitis B - Pipeline by Abivax SA 74
Hepatitis B - Pipeline by AiCuris GmbH & Co KG 74
Hepatitis B - Pipeline by AIMM Therapeutics BV 75
Hepatitis B - Pipeline by Akshaya Bio Inc 75
Hepatitis B - Pipeline by Alnylam Pharmaceuticals Inc 76
Hepatitis B - Pipeline by Altimmune Inc 76
Hepatitis B - Pipeline by Altravax Inc 77
Hepatitis B - Pipeline by Amarna Therapeutics BV 77
Hepatitis B - Pipeline by Arbutus Biopharma Corp 78
Hepatitis B - Pipeline by Arcturus Therapeutics Inc 79
Hepatitis B - Pipeline by Arrowhead Pharmaceuticals Inc 79
Hepatitis B - Pipeline by Assembly Biosciences Inc 80
Hepatitis B - Pipeline by Beijing Kawin Technology Share-Holding Co Ltd 80
Hepatitis B - Pipeline by Beijing Minhai Biotechnology Co Ltd 81
Hepatitis B - Pipeline by Benitec Biopharma Ltd 81
Hepatitis B - Pipeline by Biological E Ltd 82
Hepatitis B - Pipeline by BioStar Pharmaceuticals Inc 82
Hepatitis B - Pipeline by Bolder Biotechnology Inc 83
Hepatitis B - Pipeline by BrightGene Bio-Medical Technology Co Ltd 83
Hepatitis B - Pipeline by Bukwang Pharm Co Ltd 84
Hepatitis B - Pipeline by CaroGen Corp 84
Hepatitis B - Pipeline by Celltrion Inc 85
Hepatitis B - Pipeline by Chong Kun Dang Pharmaceutical Corp 85
Hepatitis B - Pipeline by Chromis Therapeutics Inc 86
Hepatitis B - Pipeline by Cocrystal Pharma Inc 86
Hepatitis B - Pipeline by ContraVir Pharmaceuticals Inc 87
Hepatitis B - Pipeline by CyTuVax BV 87
Hepatitis B - Pipeline by Dicerna Pharmaceuticals Inc 88
Hepatitis B - Pipeline by Dong-A Socio Holdings Co Ltd 88
Hepatitis B - Pipeline by Dynavax Technologies Corp 89
Hepatitis B - Pipeline by Ensemble Therapeutics Corp 89
Hepatitis B - Pipeline by Enyo Pharma SA 90
Hepatitis B - Pipeline by eTheRNA Immunotherapies NV 90
Hepatitis B - Pipeline by F. Hoffmann-La Roche Ltd 91
Hepatitis B - Pipeline by GeneCure LLC 91
Hepatitis B - Pipeline by GeoVax Labs Inc 92
Hepatitis B - Pipeline by Gilead Sciences Inc 92
Hepatitis B - Pipeline by GlaxoSmithKline Plc 93
Hepatitis B - Pipeline by Green Cross Corp 93
Hepatitis B - Pipeline by Hanmi Pharmaceuticals Co Ltd 94
Hepatitis B - Pipeline by Humabs BioMed SA 94
Hepatitis B - Pipeline by Huons Co Ltd 95
Hepatitis B - Pipeline by Ildong Pharmaceutical Co Ltd 95
Hepatitis B - Pipeline by Immunotope Inc 96
Hepatitis B - Pipeline by Indian Immunologicals Ltd 96
Hepatitis B - Pipeline by Intellia Therapeutics Inc 97
Hepatitis B - Pipeline by Ionis Pharmaceuticals Inc 97
Hepatitis B - Pipeline by ISA Pharmaceuticals BV 98
Hepatitis B - Pipeline by Jiangsu Hansoh Pharmaceutical Group Co Ltd 98
Hepatitis B - Pipeline by Johnson & Johnson 99
Hepatitis B - Pipeline by Kineta Inc 99
Hepatitis B - Pipeline by Leukocare AG 100
Hepatitis B - Pipeline by LG Chem, Ltd. 100
Hepatitis B - Pipeline by Ligand Pharmaceuticals Inc 101
Hepatitis B - Pipeline by Medivir AB 101
Hepatitis B - Pipeline by Mucosis BV 102
Hepatitis B - Pipeline by MultiCell Technologies Inc 102
Hepatitis B - Pipeline by Oncolys BioPharma Inc 103
Hepatitis B - Pipeline by Panacea Biotec Ltd 103
Hepatitis B - Pipeline by Pfenex Inc 104
Hepatitis B - Pipeline by PharmaEssentia Corp 104
Hepatitis B - Pipeline by Profarma 105
Hepatitis B - Pipeline by Profectus BioSciences Inc 105
Hepatitis B - Pipeline by Replicor Inc 106
Hepatitis B - Pipeline by Rodos BioTarget GmbH 106
Hepatitis B - Pipeline by Samjin Pharmaceutical Co Ltd 107
Hepatitis B - Pipeline by Sanofi 107
Hepatitis B - Pipeline by Sanofi Pasteur SA 108
Hepatitis B - Pipeline by Scynexis Inc 108
Hepatitis B - Pipeline by Shantha Biotechnics Ltd 109
Hepatitis B - Pipeline by Sinovac Biotech Ltd 109
Hepatitis B - Pipeline by Spring Bank Pharmaceuticals Inc 110
Hepatitis B - Pipeline by TCM Biotech International Corp 110
Hepatitis B - Pipeline by Theravectys SA 111
Hepatitis B - Pipeline by THEVAX Genetics Vaccine USA Inc 111
Hepatitis B - Pipeline by Tomegavax Inc 112
Hepatitis B - Pipeline by Transgene SA 112
Hepatitis B - Pipeline by Vaxine Pty Ltd 113
Hepatitis B - Pipeline by VBI Vaccines Inc 113
Hepatitis B - Pipeline by Vical Inc 114
Hepatitis B - Pipeline by ViroStatics srl 114
patitis B - Pipeline by VLP Biotech Inc 115
Hepatitis B - Pipeline by Zydus Cadila Healthcare Ltd 115
Hepatitis C - Pipeline by 3-V Biosciences Inc 116
Hepatitis C - Pipeline by AbbVie Inc 116
Hepatitis C - Pipeline by AIMM Therapeutics BV 117
Hepatitis C - Pipeline by Akshaya Bio Inc 117
Hepatitis C - Pipeline by Amarillo Biosciences Inc 118
Hepatitis C - Pipeline by Amarna Therapeutics BV 118
Hepatitis C - Pipeline by ARA Healthcare Pvt Ltd 119
Hepatitis C - Pipeline by Aviragen Therapeutics Inc 119
Hepatitis C - Pipeline by Beijing Kawin Technology Share-Holding Co Ltd 120
Hepatitis C - Pipeline by Beta Pharma Inc 120
Hepatitis C - Pipeline by Biocad 121
Hepatitis C - Pipeline by Biotest Pharmaceuticals Corp 121
Hepatitis C - Pipeline by Biotron Ltd 122
Hepatitis C - Pipeline by Boehringer Ingelheim GmbH 122
Hepatitis C - Pipeline by Bolder Biotechnology Inc 123
Hepatitis C - Pipeline by Bristol-Myers Squibb Company 123
Hepatitis C - Pipeline by Cocrystal Pharma Inc 124
Hepatitis C - Pipeline by Conatus Pharmaceuticals Inc 124
Hepatitis C - Pipeline by ContraVir Pharmaceuticals Inc 125
Hepatitis C - Pipeline by DEKK-TEC Inc 125
Hepatitis C - Pipeline by Delpor Inc 126
Hepatitis C - Pipeline by F. Hoffmann-La Roche Ltd 126
Hepatitis C - Pipeline by Formune SL 127
Hepatitis C - Pipeline by Genecode AS 127
Hepatitis C - Pipeline by GeneCure LLC 128
Hepatitis C - Pipeline by Gilead Sciences Inc 128
Hepatitis C - Pipeline by GinkgoPharma Co Ltd 129
Hepatitis C - Pipeline by GlaxoSmithKline Plc 129
Hepatitis C - Pipeline by HanAll Biopharma Co Ltd 130
Hepatitis C - Pipeline by ImmunoBiology Ltd 130
Hepatitis C - Pipeline by ImmunoClin Corp 131
Hepatitis C - Pipeline by Immunotope Inc 131
Hepatitis C - Pipeline by Inovio Pharmaceuticals Inc 132
Hepatitis C - Pipeline by Integrated BioTherapeutics Inc 132
Hepatitis C - Pipeline by JN-International Medical Corp 133
Hepatitis C - Pipeline by Johnson & Johnson 133
Hepatitis C - Pipeline by Karyopharm Therapeutics Inc 134
Hepatitis C - Pipeline by Kineta Inc 134
Hepatitis C - Pipeline by Ligand Pharmaceuticals Inc 135
Hepatitis C - Pipeline by Medivir AB 135
Hepatitis C - Pipeline by Merck & Co Inc 136
Hepatitis C - Pipeline by Microbio Co Ltd 137
Hepatitis C - Pipeline by Microbiotix Inc 137
Hepatitis C - Pipeline by MultiCell Technologies Inc 138
Hepatitis C - Pipeline by NeuroVive Pharmaceutical AB 138
Hepatitis C - Pipeline by Novalex Therapeutics Inc 139
Hepatitis C - Pipeline by Novartis AG 139
Hepatitis C - Pipeline by NovaTarg Therapeutics Inc 140
Hepatitis C - Pipeline by Ono Pharmaceutical Co Ltd 140
Hepatitis C - Pipeline by Pfenex Inc 141
Hepatitis C - Pipeline by Pfizer Inc 141
Hepatitis C - Pipeline by PharmaEssentia Corp 142
Hepatitis C - Pipeline by Presidio Pharmaceuticals Inc 142
Hepatitis C - Pipeline by Profectus BioSciences Inc 143
Hepatitis C - Pipeline by Replicor Inc 143
Hepatitis C - Pipeline by Rodos BioTarget GmbH 144
Hepatitis C - Pipeline by Solon Eiendom ASA 144
Hepatitis C - Pipeline by SomaGenics Inc 145
Hepatitis C - Pipeline by Sorrento Therapeutics Inc 145
Hepatitis C - Pipeline by Sudershan Biotech Ltd 146
Hepatitis C - Pipeline by TaiGen Biotechnology Co Ltd 146
Hepatitis C - Pipeline by TaiwanJ Pharmaceuticals Co Ltd 147
Hepatitis C - Pipeline by Therapure Biopharma Inc 147
Hepatitis C - Pipeline by Theravectys SA 148
Hepatitis C - Pipeline by THEVAX Genetics Vaccine USA Inc 148
Hepatitis C - Pipeline by Vakzine Projekt Management GmbH 149
Hepatitis C - Pipeline by Vertex Pharmaceuticals Inc 149
Hepatitis C - Pipeline by WhanIn Pharmaceutical Co Ltd 150
Hepatitis C - Pipeline by Zylacta Corp 150
Hepatitis D - Pipeline by Alnylam Pharmaceuticals Inc 151
Hepatitis D - Pipeline by Eiger BioPharmaceuticals Inc 151
Hepatitis D - Pipeline by F. Hoffmann-La Roche Ltd 152
Hepatitis D - Pipeline by Globeimmune Inc 152
Hepatitis D - Pipeline by Replicor Inc 153
Hepatitis D - Pipeline by Rodos BioTarget GmbH 153
Hepatitis D - Pipeline by SomaGenics Inc 154
Hepatitis D - Pipeline by Spring Bank Pharmaceuticals Inc 154
Hepatitis A - Dormant Projects 155
Hepatitis B - Dormant Projects 155
Hepatitis C - Dormant Projects 159
Hepatitis D - Dormant Projects 169
Hepatitis B - Discontinued Products 170
Hepatitis C - Discontinued Products 170
Hepatitis D - Discontinued Products 173

List of Figures
List of Figures
Number of Products under Development for Hepatitis A 13
Number of Products under Development by Companies, Hepatitis A 14
Number of Products under Development by Universities/Institutes, Hepatitis A 15
Number of Products under Development for Hepatitis B 17
Number of Products under Development by Companies, Hepatitis B 18
Number of Products under Development by Universities/Institutes, Hepatitis B 22
Number of Products under Development for Hepatitis C 30
Number of Products under Development by Companies, Hepatitis C 31
Number of Products under Development by Universities/Institutes, Hepatitis C 34
Number of Products under Development for Hepatitis D 43
Number of Products under Development by Companies, Hepatitis D 44
Number of Products by Molecule Types, Hepatitis A 46
Number of Products by Stage and Molecule Types, Hepatitis A 47
Number of Products by Top 10 Targets, Hepatitis B 48
Number of Products by Stage and Top 10 Targets, Hepatitis B 48
Number of Products by Top 10 Mechanism of Actions, Hepatitis B 50
Number of Products by Stage and Top 10 Mechanism of Actions, Hepatitis B 50
Number of Products by Top 10 Routes of Administration, Hepatitis B 52
Number of Products by Stage and Top 10 Routes of Administration, Hepatitis B 52
Number of Products by Top 10 Molecule Types, Hepatitis B 54
Number of Products by Stage and Top 10 Molecule Types, Hepatitis B 54
Number of Products by Top 10 Targets, Hepatitis C 56
Number of Products by Stage and Top 10 Targets, Hepatitis C 56
Number of Products by Top 10 Mechanism of Actions, Hepatitis C 59
Number of Products by Stage and Top 10 Mechanism of Actions, Hepatitis C 59
Number of Products by Routes of Administration, Hepatitis C 62
Number of Products by Stage and Routes of Administration, Hepatitis C 62
Number of Products by Top 10 Molecule Types, Hepatitis C 64
Number of Products by Stage and Top 10 Molecule Types, Hepatitis C 64
Number of Products by Targets, Hepatitis D 65
Number of Products by Stage and Targets, Hepatitis D 66
Number of Products by Mechanism of Actions, Hepatitis D 67
Number of Products by Stage and Mechanism of Actions, Hepatitis D 67
Number of Products by Routes of Administration, Hepatitis D 69
Number of Products by Stage and Routes of Administration, Hepatitis D 69
Number of Products by Molecule Types, Hepatitis D 70
Number of Products by Stage and Molecule Types, Hepatitis D 71

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